Puffy eyelids in the morning are usually considered physiological edema or pathologic edema due to kidney disease or eyelid disease. 1. Physiological edema: if you drink a lot of water before going to bed or stay up late for a long time, it is easy to cause edema in the eyelids and other loose connective tissue areas. 2. Pathological edema: if the patient is considered to have renal insufficiency and other renal diseases, ocular edema can occur along with proteinuria, hematuria and other symptoms. If the eyelid is swollen unilaterally, it may be caused by eyelid lesions such as granuloma. In addition, morning eyelid swelling can not be ruled out due to other parts of the heart, liver, thyroid and other diseases caused by eyelid swelling. If you have morning eyelid swelling and other related symptoms, you should go to the hospital in time for a clear diagnosis and targeted treatment.