The four stages of mastocytosis

  1, breast pain mainly seen in adolescent or young women, before the period there is obvious breast swelling, pain, sometimes the pain can extend to the back of the shoulder, local pain and vibration type pain. After menstruation, breast pain and swelling gradually relieve themselves, and there is a sense of relaxation. These patients often have dysmenorrhea, menstrual disorders and menstrual tension. In remission, there is only a sensation of breast thickening and no nodules can be found. This syndrome is within the scope of physiological changes.  2. Lobular hyperplasia is the most common clinical stage of breast enlargement, mostly seen in young women aged 20-30. The main manifestation is premenstrual breast pain and discomfort, and when the pain increases, it can extend to the back of the shoulder and the armpit. Nodules of different sizes or thickened lamellar tissue can be found in the breast. After menstruation, the nodules shrink and the tissue becomes soft, but the nodules are difficult to fade completely. The lesions are more often distributed in the outer upper quadrant of the breast or are diffusely distributed. At this stage, there are obvious signs of glandular epithelial hyperplasia in the pathology.  3. Breast fibroadenoma or papillomatosis develops further from lobular hyperplasia. The clinical manifestations are often synchronous and uniform thickening of the entire breast, and small nodules or fibroadenomas with clear borders can be found in individual areas, which can be multiple small lesions with a certain degree of activity, but no pressure pain, and do not disappear after menstruation. At this stage, pathologically, if glandular epithelial and fibrous tissue proliferation is the main cause, then it can be derived into fibroadenoma; if the ductal epithelium is papillary proliferation, then it can develop into papilloma. If it is a papillary hyperplasia of the ductal epithelium, it can develop into papilloma. If it occurs at the edge of the gland and is multiple, it becomes papillomatosis and has a high rate of cancer.  4, fibrocystic hyperplasia or sclerosing mastopathy is the result of chronic hyperplasia and cystic changes in the diffuse breast. It occurs mostly in women over 30 years old. The whole breast is firm, thickened, or flattened, with a smooth surface or nodular, without pressure pain. When cysts are formed, they appear as scattered, multiple nodules of different sizes in the breast. Patients often seek medical attention because of nodules in the breast; some patients may have plasma or plasma-blood nipple discharge; a few patients may also have enlarged axillary lymph nodes, or even cancer.