For mild diabetes mellitus, there is no need to enter prostaglandin treatment, but for obvious diabetes mellitus, once serious comorbidities occur, especially in the combination of chronic atherosclerosis and occlusion, especially thrombus occlusion and lead to vasculitis, or chronic atherosclerosis and chronic ulceration of limbs, diabetes mellitus combined with microcirculation disorders, which cause limb rest pain, peripheral neuritis, once the above comorbidities occur in diabetic patients, it is recommended to apply prostaglandin for symptomatic treatment. When diabetic patients have the above complications, it is recommended to apply prostaglandin for symptomatic treatment, prostaglandin can inhibit platelet aggregation, thromboxane A generation within the atherosclerotic plaque to stop plaque formation, and can expand peripheral arterial and coronary arteries, especially for the diabetes mellitus combined with the above vascular diseases have obvious efficacy, and the diabetes mellitus combined with the above vascular diseases.