Tacrolimus can be used during the day for vitiligo, but sun exposure needs to be avoided and the medication should be used during the day with sun protection. Vitiligo is an acquired depigmentation of the skin and mucous membranes. Tacrolimus belongs to the calcium-modulated phosphatase inhibitors in topical medications, and avoiding sun exposure is effective. Tacrolimus is indicated for adults and children with vitiligo, and is more adapted to mucous membranes, face and thin tender areas. The treatment of vitiligo includes topical medication, phototherapy, internal medication, depigmentation and epidermal transplantation. Topical medications include glucocorticoid preparations, calcium-modulated phosphatase inhibitors such as tacrolimus ointment and pimecrolimus cream, and vitamin D3 derivatives such as calcipotriol ointment. Phototherapy with 308nm excimer laser and NB-UVB. internal medication includes oral or injectable glucocorticosteroids, which are used only in patients with progressive stages. Traditional Chinese medicine includes oral vitiligo pills. It is recommended to seek medical advice and use medication as prescribed by the doctor.