Hepatitis B 1, 3 and 5 positive usually means hepatitis B major triple positive, which means that hepatitis B virus is more actively replicated and more infectious, and the hepatitis B viral load can be determined by hepatitis B HBV-DNA. High viral load is the high incidence of cirrhosis and liver cancer, so if the viral load is high and there are indications for treatment, antiviral treatment should be carried out as early as possible. The goal of antiviral treatment is to inhibit the replication of hepatitis B virus to the maximum extent, reduce the occurrence of cirrhosis and liver cancer, improve the quality of life and prolong life expectancy. Patients with hepatitis B major triple yang need to have regular checkups of liver function, hepatitis B two-to-one, HBV-DNA, as well as fetoprotein and liver ultrasound. Timely checkups can detect liver cancer at an early stage, and liver cancer has a good prognosis when detected early, otherwise it can be life-threatening.