Whether it is important to have high ApoE only needs to be judged in the light of the patient’s condition. High ApoE may be caused by pregnancy phenomenon, drug effects, liver disease and other reasons. 1. Pregnancy: ApoE level in women’s body is usually higher than normal during pregnancy, which is a normal physiological phenomenon and does not matter, and usually improves after pregnancy. 2. Drugs: Taking certain drugs may also cause high ApoE, such as anti-epileptic drugs, in this case, it does not matter, usually the ApoE index will return to normal after stopping the drug. 3. Liver disease: If the patient suffers from liver disease, it may also lead to high ApoE, such as chronic hepatitis, liver disease and other diseases, liver disease will affect the synthesis of ApoE in the body abnormally, then need to pay attention. If the patient is not pregnant or not taking medication, it is recommended that the patient go to the hospital for further examination in case the high ApoE is caused by a disease.