Blisters on peeling feet (i.e. “blisters”) may be caused by physiological factors (e.g. local friction, etc.) or pathological factors (e.g. eczema, tinea pedis, etc.), and should be relieved by general treatment and medication according to the cause. 1. Physiological factors: If the feet are subject to repeated friction, such as inappropriate shoes and socks, the skin may blister or blisters, and flaking may occur after the blisters rupture. Patients are advised to change comfortable shoes and socks, and no special treatment is needed. If the blisters are too big, a sterile syringe can be used to puncture the blisters under doctor’s guidance and after fully sterilized, meanwhile, the local area should be kept dry and clean to avoid infection. 2. Pathological factors: (1) Eczema: If there is eczema on the feet, it will lead to small blisters on the feet with intense itching, oozing and flaking. Glucocorticoid creams such as tretinoin cream can be used externally, and antihistamines such as loratadine and cetirizine can be taken orally. (2) Tinea pedis: Fungal infections may cause blisters, itching, oozing, and ulceration in the cracks of the toes. When the blister breaks out and oozing occurs, boric acid solution can be used externally as a wet compress; when the blister dries up and no oozing occurs, ketoconazole cream and miconazole nitrate cream can be used externally; if the symptoms are more serious, it is necessary to follow the doctor’s instructions to take itraconazole capsules and terbinafine hydrochloride tablets for treatment. It is recommended that patients seek timely medical care, first clear cause, and actively cooperate with the doctor to use medication.