Awakening at 3-5 a.m. is also called early awakening, if the patient is of advanced age, wakes up early once in a while, can continue to sleep after waking up, etc., it is usually normal and does not require special treatment; if the patient wakes up for a long time at this time or with other typical clinical manifestations, it may be due to disease causes: 1. Insomnia: Insomnia patients can cause sleep quality and quantity to fail to meet due to difficulties in falling asleep or sleep maintenance normal physiological needs, manifested as easy to wake up early, difficulty in falling asleep, etc. For such cases, patients can adjust their work and rest, drink milk and dates before bed to help them fall asleep to a certain extent to improve the symptoms of early awakening, and if necessary, use benzodiazepine receptor agonists, melatonin receptor agonists and other drug therapy under the guidance of a doctor; 2, depression: depression patients with sleep disorders mainly manifested as early awakening, and can not fall asleep again after waking, and can be accompanied by significant and persistent emotional depression, depression and pessimism, and in serious cases can produce light thoughts. Therefore, such patients need to go to the relevant psychological clinic for treatment in time to avoid adverse consequences; 3, other: some organic diseases, such as sleep apnea syndrome, obstructive lung disease, coronary heart disease, heart failure, gastroesophageal reflux and other diseases patients may wake up early due to choking sensation, angina pectoris, gastrointestinal vomiting and other uncomfortable reasons, need to actively treat the original disease in order to improve the symptoms of early waking.