Cold fever in the middle of the night can be treated with physical cooling and medication, etc. If there is no significant relief, you need to go to the hospital immediately. 1. Physical cooling: if the fever is not more than 38.5℃, you can use warm water bath, such as forehead, groin, bilateral armpit and other large blood vessels through the location, to promote heat dissipation. 2. Drugs to reduce temperature: when the fever is above 38.5℃ in the middle of the night of cold and flu, you can use acetaminophen, ibuprofen and other drugs to reduce temperature, the use of drugs should be carried out under the guidance of the doctor. Especially children, pregnant women and other special groups of people need to consult a doctor for the use of drugs. The above methods can usually help to reduce fever, the occurrence of fever in the middle of the night is recommended to go to the hospital as soon as possible, improve the relevant laboratory tests to assess the condition, under the guidance of the doctor for standardized treatment.