Acute hepatitis D, one of the clinical diagnoses of viral hepatitis D, is defined as HDV/HBV co-infection. The incubation period is 4 to 20 weeks. The clinical presentation and biochemical features are similar to those of simple acute hepatitis B. There may be malaise, lack of appetite, jaundice and hepatomegaly. What are the screening tests for only a transient positive intrahepatic HDAg? Screening items: Liver function tests, plasma coagulation factor II activity assay, blood donor health screening, humoral immunoassay, 1-minute bilirubin, routine physical examination, urine copper, hepatitis A antigen, fetal globulin A test, argininosuccinate lyase, A-Mann’s test, liver prothrombin test The possibility of transformation to chronic hepatitis obviously differs between acute infections with different hepatitis viruses. In acute hepatitis A and E virus infection, after the acute phase, the disease is self-limiting and the prognosis is good, no persistent carriage of the virus occurs, and no transformation into chronic hepatitis or cirrhosis; about 15% of acute hepatitis B is transformed into chronic hepatitis, about 20% develops into cirrhosis and about 0.6% develops liver cancer; about 36% (26%-55%) of hepatitis C is also transformed into chronic hepatitis. Laboratory diagnosis: 1, pathogenesis should be tested for hepatitis B, C, D viral markers, if the acute attack should be checked for A, E and other viral markers to determine whether there is overlap infection. 2, biochemical indicators should be checked ALT, Bi1, T/A, Ep, PA. light, moderate and severe type III biochemical index values can be referred. Other tests include blood picture (especially white blood cell and platelet count should be noted). 3. Urine routine (special attention should be paid to urine protein and red blood cells to identify extrahepatic manifestations).