Eighteen-month-old baby vaccine rash is usually caused by an allergic reaction to the vaccine, can be under the guidance of the doctor through the life conditioning, oral medication, topical medication and other ways to alleviate the symptoms. 1. Life management: parents should pay attention to avoid excessive scratching of the baby’s hands, so as to avoid the invasion of bacteria or germs on the hands, resulting in a more serious part of the rash. Do not eat spicy and stimulating food, and not wash the affected area with water that is too hot, so as not to cause irritation. 2. Oral medication: antihistamines such as levocetirizine hydrochloride oral solution and desloratadine dry suspension can be taken orally under the guidance of a doctor to alleviate the symptoms of allergic reactions in babies. 3. Topical medication: If the rash is large and accompanied by obvious itching symptoms, glycerine lotion can be applied to the affected area, but should not be applied to the eye of the needle. If necessary, hormonal drugs should also be used for treatment, such as dexamethasone tablets and mometasone furoate cream. Parents are advised to take their babies to the doctor in time, and the medication must be administered in strict accordance with the doctor’s advice, not at random, to avoid serious complications.