What are the chemotherapeutic drugs used in neuro-oncology chemotherapy? Chemotherapy drugs for neuro-oncology chemotherapy are very important for patients. No matter which disease it is, once it occurs, it should be treated in time. Chemotherapeutic drugs for neuro-oncology 1. Nitrosoureas: Before temozolomide entered clinical treatment, nitrosoureas were the main therapeutic drugs for malignant glioma because they could better cross the blood-brain barrier. For example, a clinical study jointly organized by RTOG and ECOG found that simultaneous radiotherapy with BCNU was significantly more effective than radiotherapy alone in the 40.age group. Further analysis showed that adjuvant chemotherapy with nitrosoureas-containing regimens increased 1-year survival by 10.1 % and 2-year survival by 8.6 %. An analysis including more than 3,000 patients with malignant glioma also showed that postoperative radiotherapy combined with postoperative chemotherapy could increase the 1-year survival rate from 40% to 46% and the median life expectancy by 2 months compared to postoperative radiotherapy alone. 2. Temozolomide: It is a newly developed alkylating agent, which is converted to MflC in vivo. It has a short half-life in vivo and can lead to DNA methylation and DNA breakage. Early studies found that temozolomide monotherapy for recurrent malignant glioma was 21% effective, much higher than methylphenidate (8%), and had a progression-free survival time of up to six months. Radiotherapy combined with temozolomide therapy has now become the standard of care for glioblastoma. Further studies also found that the level of MGMT (6-methylguanine methyltransferase) protein expression determined which fraction of malignant gliomas were effective with temozolomide. temozolomide treatment was significantly more effective in the group of patients with methylation of the MGMT promoter, while temozolomide treatment was mostly ineffective in patients without methyl palladium of the MGMT promoter. Common therapeutic adverse effects of temozolomide include nausea, vomiting, decreased appetite, fatigue and headache, and mostly mild bone marrow toxicity. 3. Other drugs: In addition to the above drugs, other drugs used for chemotherapy of CNS malignancies include methylbenzylhydrazine, irinotecan, platinum-containing regimens and so on. These drugs are mostly used in the second-line treatment of malignant glioma.