Patient: Hello! I am a parent of a high school student in Nanchang, Jiangxi. My daughter has been feeling pain in her left calf since the beginning of this year, and since my child is about to take the college entrance exam, I promised her to see a doctor after the exam. However, in April, her pain worsened and I took her to Nanchang First Affiliated Hospital for MR and CT films. The imaging performance was described as follows: a large mixed-signal mass with a size of about 7*7 cm and a length of about 15.5 cm was seen in the posterior muscle space from the left N fossa to the upper calf, with clear and regular borders and a relatively bright appearance, with low signal in T1WI and high signal in T2WI. The surrounding muscles were compressed and pushed. A soft tissue signal shadow of about 1.5*2cm in size, with long T1WI and long T2WI signals, with clear and well-defined borders, can also be seen below it. The hospital’s opinion: multiple occupations in the posterior muscle space of the upper left calf, combined with the medical history, mostly consider neurofibromatosis. I would like to ask how difficult is the surgery? Is it possible to preserve the limb for treatment. Patient: Hello I have uploaded the CT film in electronic file, please help to see, thanks again! Doctor: Surgery is not a problem, the most critical thing is to clarify the nature of the tumor first, it is recommended to come to the hospital for biopsy and then determine the treatment method, if it is neurofibromatosis definitely need to preserve the limb, even if it is malignant we will do our best to preserve the limb. Patient: Hello,? My daughter had a resection and pathological section done at Nanchang First Affiliated Hospital as soon as the entrance exams were over, suggesting that it was a malignant neurofibroma, so please ask what the next step is. Doctor: It mainly depends on the scope of surgical resection. Generally, extensive resection is required, if not, extended resection can be done, and it is recommended to go to a professional bone tumor hospital.