Women with genital herpes are able to have safe pregnancies and normal vaginal deliveries. This is especially true in women who have been diagnosed with genital herpes prior to pregnancy. In cases where a pregnant woman already has a history of genital herpes infection, antibodies are present in her bloodstream and will protect the fetus during pregnancy and delivery. The fetus is at risk of herpes infection only in two cases: a severe first episode in early pregnancy (within the first 12 weeks of pregnancy), which can lead to miscarriage. This is rare. The risk is equally present in the case of many other viral infections, including influenza. When an initial attack occurs in the second trimester (last trimester), a large amount of virus is present in the mother’s body and there is not enough time to produce antibodies to protect the fetus. Transmission of the virus to the fetus can result in neonatal herpes in particular, which can lead to neonatal death. However, neonatal herpes is extremely rare in developed countries. Careful monitoring, judicious use of antiviral therapy and/or cesarean section can reduce the risk of this neonatal infection. If a pregnant woman has genital herpes herself or her sexual partner, it is important to inform her doctor about this condition. The doctor will take appropriate measures and advice to help the patient take countermeasures. The safety of acyclovir in pregnant women has not been established, but studies have found that the incidence of malformations in pregnant women treated with acyclovir is not increased compared to normal subjects, but no reliable conclusions have been made about the risk of acyclovir to pregnancy and the fetus. Acyclovir should be used intravenously for life-threatening HSV infections such as encephalitis, pneumonia, and hepatitis, but systemic acyclovir is not necessary for non-life-threatening HSV infections.