If the total bilirubin 22.2 is high, it is necessary to be judged by the doctor according to the specific cause, because the causes of total bilirubin can be divided into physiological factors such as strenuous exercise, high oil and high fat diet, drinking alcohol, etc., and pathologic factors such as hemolytic jaundice, choledocholithiasis, choledochal tumors and so on. 1. Physiological factors: such as strenuous exercise, high oil and high fat diet, drinking alcohol, etc., can lead to elevated total bilirubin, but it is a normal physiological reaction, usually can be normalized within a few days, and is not serious. You need to pay attention to regular diet and eat more vegetables and fruits. 2. Pathological factors: such as hemolytic jaundice, choledocholithiasis, bile duct tumors, etc., need to be vigilant, and it is recommended to consult a doctor in time for blood biochemistry, abdominal CT, X-ray and other auxiliary examinations to find out the cause of the disease, and actively treat it. It is recommended that patients seek timely medical treatment and choose the appropriate treatment and medication under the guidance of the doctor.