Breast nodule with clear boundary and irregular pattern 4a means that the nodule has cancer risk and further examination is needed to clarify the diagnosis. Generally, grade 1~2 breast nodules are benign nodules with clear boundary and regular morphology, grade 3 and above have certain possibility of malignancy, and irregular morphology and grade 4a indicate that the nodules have 2%~10% risk of cancer, and further biopsy and pathologic examination are needed to clarify whether the nodules are malignant or not. If the nodule is benign, it needs to be followed up and observed. If it is malignant, it needs to be treated with surgery, radiotherapy, chemotherapy, hormone therapy, etc. If the nodule is malignant, it needs to be treated with surgery. It is recommended to go to the Department of Nail and Breast Surgery or Department of Oncology in the hospital in time to clarify the nature of the nodule, so as to take corresponding treatment measures to avoid delaying the condition.