Whether or not proteinuria of 0.5 g/d is serious depends mainly on its cause and cannot be generalized. Physiological causes of urinary protein is usually not serious, pathological causes of urinary protein without timely standardized intervention and treatment may be the progress of the disease, this situation is more serious. Normal human urine protein value & lt; 0.15g / d, urine protein 0.5g / d belongs to urine protein positive. It can be divided into physiologic proteinuria and pathologic proteinuria. Physiological proteinuria is more common in strenuous exercise, fever and other conditions, the patient’s kidneys without organic lesions, without special treatment, after resting, urine protein can usually turn negative on its own, usually does not appear more serious. Pathological proteinuria is usually caused by organic lesions of the kidneys, usually persistent proteinuria, and its common causes are glomerulonephritis, urinary tract infections, urinary stones and so on. If the primary disease is not timely and standardized treatment, it may cause the progression of the primary disease, and then aggravate proteinuria, the gradual decline of renal function, and in severe cases may even lead to uremia. If the patient found urine protein positive, it is recommended to go to the regular hospital in time, complete the examination to clarify the cause of the disease, under the guidance of the doctor to targeted treatment or treatment.