Early stages of lymphoma can present with itchy skin all over the body with no fixed location. Itching is sometimes the only symptom of lymphoma. Itchy skin is more common within Hodgkin’s lymphoma. Itching is categorized into localized skin itching, which is often found at the site of the lesion, and generalized itching, which is often found in the abdomen or mediastinum. The mechanism of itching is not clear, but it may be caused by the stimulation of sensory nerve endings by active substances produced by the tumor tissue that reach the skin. In addition to generalized itching, early stage of lymphoma may also present with unexplained progressive enlargement of painless lymph nodes, irregular fever, night sweating, weight loss, etc. If the above symptoms occur, one should consult a doctor promptly. If the above symptoms occur, one should consult the doctor in time to find out the cause of the disease so as not to miss the best time for treatment.