Lung nodules found after two chemotherapy treatments for Hodgkin’s lymphoma should be compared with previous CT to evaluate the nature of the lung nodules, and if no previous CT examination is performed, the changes of the nodules should be followed up, and PET-CT should be examined if necessary. Lung nodules are a common clinical sign, and most of them are benign, such as lung inflammation, tuberculosis, etc. The nodules can be reduced after active symptomatic treatment, and regular follow-up can be performed thereafter. If malignancy is considered, PET-CT can be performed to evaluate the lesion. If Hodgkin’s lymphoma metastasis is considered to be the cause of pulmonary nodules, it suggests that the patient’s condition has progressed, and a change of treatment should be considered in order to achieve a better therapeutic effect. It is recommended that the patient actively improve the relevant examinations to clarify the nature of the nodules and actively treat them to avoid delaying the condition.