Myocardial infarction refers to myocardial infarction. Ventricular fibrillation in patients with myocardial infarction requires defibrillation measures for symptomatic treatment, as well as general measures, medication, and surgery for causative treatment. 1. Symptomatic treatment: after the occurrence of ventricular fibrillation, patients should first take asynchronous biphasic electric defibrillation, which is an effective method to convert ventricular fibrillation to normal heart rate. If electric defibrillation is not effective, it is necessary to use drugs to defibrillate, such as amiodarone, lidocaine, procainamide, etc. If it is not sensitive to drugs, it is necessary to use drugs to defibrillate. If it is not sensitive to drugs, implantable cardioverter-defibrillator should be considered. 2. Treatment: For myocardial infarction, doctors will give patients thrombolytic drugs such as streptokinase, urokinase, alteplase, and antithrombotic drugs such as aspirin and clopidogrel in a timely manner. Patients also need to follow the doctor’s instructions to use nitroglycerin, isosorbide mononitrate and other drugs to dilate the coronary arteries. For the onset of time within 12 hours of the patient, the need for percutaneous coronary intervention, if the treatment is ineffective, the need to take emergency coronary artery bypass grafting. In conclusion, myocardial infarction patients with ventricular fibrillation need immediate cardiopulmonary resuscitation, and timely access to hospitals for a series of standardized treatment, so as not to delay the condition.