Hypoechoic nodule next to the nipple at 6 o’clock of the left breast and 8 o’clock of the right breast, the possible causes are fibroadenoma of the breast on the lower side of the left breast and on the inner side of the right breast, breast cancer, cystic hyperplasia of the breast and so on. 1. Breast fibroadenoma: the most common benign breast tumor. It is composed of hyperplastic breast fibrous tissue and glandular ducts. Ultrasonographic manifestation is a round lump with internal uniform hypoechoicity, which can be manifested as a hypoechoic nodule next to the nipple at 6 o’clock in the left breast and 8 o’clock in the right breast. 2. Breast cancer: it is a malignant tumor of the breast, with uneven hypoechoicity inside the mass. Estrone and estradiol secreted by the mammary glands are related to the development of breast cancer, and breast ultrasound can show hyperechoic nodules at 6 o’clock of the left breast and 8 o’clock of the right breast next to the nipple. 3. Breast cystic hyperplasia: The pathology of breast cystic hyperplasia is diversified, hyperplasia can occur around the milk ducts, accompanied by cysts of varying sizes, and mammography can show hypoechoic nodules next to the nipple at 6 o’clock on the left breast and 8 o’clock on the right breast. Don’t use medication on your own in the presence of hypoechoic breast area, you need to seek medical treatment as soon as possible to avoid serious complications.