There are several possible reasons for nose bleeding in advanced cancer: i. Patients with advanced cancer are often accompanied by impairment of coagulation function, significantly prolonged clotting time, increased risk of bleeding, and rich capillaries in the nasal mucosa area, so they are prone to bleeding. Second, advanced cancer causes nasal bleeding due to side effects of chemotherapy or cancer bone marrow metastasis, which inhibits hematopoietic function and other reasons, resulting in a significant decrease in the number of platelets responsible for hemostasis in the patient’s blood. Nasopharyngeal tumor or tumors from other parts metastasize to the nasopharynx, invading blood vessels and causing nasal bleeding. The amount of food eaten by patients with advanced cancer is obviously reduced, and the lack of vitamins, trace elements and other nutrients in food is obvious, resulting in increased brittleness and permeability of blood vessels, which makes patients bleed easily. V. Some chemotherapy drugs or targeted therapy drugs used in the late stage of cancer have the side effect of causing nasal bleeding, such as the commonly used anti-angiogenic targeted therapy drugs.