Numbness of legs caused by peripheral nerves can be given drugs to nourish the nerves and promote blood circulation, and the treatment methods are different according to the different causes of the disease. 1. Nutritional nerve drugs generally include: methylcobalamin, vitamin B1, and vitamin B12, etc. If the nerve endings disease is caused by diabetes mellitus, it should also be actively controlled by blood glucose, according to the condition of insulin, sulfonamides and other hypoglycemic drugs. 2. Local blood circulation disorder: if it is vasculitis, thrombosis and other causes of insufficient blood supply, loss of nerve endings, should be given to safflower, danshen drip pills, ginkgo biloba, etc. to improve local blood flow. To summarize, leg numbness caused by peripheral nerve injury should be treated symptomatically and causally under the guidance of a doctor, long-term smokers and drinkers should pay attention to smoking and alcohol cessation, and those with lumbar spine lesions compressing the nerves should be given medication or surgical treatment. It is recommended that patients should consult a doctor in time, and should not blindly treat themselves to avoid delaying or aggravating the condition.