The chances of hypertensive nephropathy progressing to uremia are not generalized, and are mainly related to the stage of the disease and treatment. If the disease is not controlled, it will lead to uremia with the development of time, but if the treatment is actively carried out in the early stage of hypertensive nephropathy, most of the patients will greatly delay the time of reaching uremia, or even life-long not to progress to uremia. In the early stage of hypertensive nephropathy, renal ischemia is mainly caused by small arteriosclerosis, which is manifested as tubular damage in the early stage and glomerular damage in the later stage. If there is no intervention, it may eventually lead to uremia with the development of time. If the antihypertensive treatment is actively carried out in the early stage of hypertensive nephropathy, so that the blood pressure is controlled below 140/90mmHg, the rate of decline of renal function can be greatly delayed, and some patients can even be lifelong without progression to uremia. However, if hypertensive nephropathy is already in the middle or late stage, even if the blood pressure is actively controlled, the renal disease may still progress gradually and eventually lead to uremia. Therefore, patients with hypertensive nephropathy need early diagnosis and strict blood pressure control to delay the progression of the disease. It is recommended that hypertensive nephropathy patients should go to the hospital in time and follow the doctor’s instructions for standardized treatment.