Hiccups with burning sensation in the esophagus are mostly caused by gastroesophageal reflux disease, peptic ulcer, hiatal hernia, increased abdominal pressure and other diseases. 1. Gastroesophageal reflux disease (GERD): It is a disease caused by reflux of stomach contents (stomach acid, bile, etc.) into the esophagus due to the damage of esophageal anti-reflux structure or function, and the decrease of mucosal resistance, etc. Its typical symptoms are acid reflux and heartburn, and when hiccups are made, the gastric acid and other substances may reflux into the esophagus, resulting in a burning sensation in the esophagus. 2. Peptic ulcer: Patients usually have increased secretion of gastric acid, which may reflux into the esophagus when burping occurs, resulting in a burning sensation in the esophagus. This may be accompanied by periodic, rhythmic abdominal pain, nausea, anorexia and other symptoms. 3. Esophageal hiatal hernia: refers to a disease in which organs or tissues in the abdominal cavity other than the esophagus enter the thoracic cavity through an enlarged esophageal hiatus in the diaphragm, and the patient’s typical symptoms are heartburn, acid reflux, etc., and there may be hiccups and burning sensation in the esophagus, and in severe cases, swallowing difficulties may also occur. 4. Increased abdominal pressure: such as pregnancy, obesity, ascites, overeating, etc., may make the abdominal pressure rise, induced by hiccups, when hiccups are more intense, it may make gastric reflux, reflux to the esophagus, will make the patient feel esophageal burning sensation. If the patient has long-term or repeated hiccups esophageal burning sensation, it is recommended to consult a doctor in a timely manner to identify the cause of the disease, targeted treatment, so as not to delay the condition.