A very sore throat and painful swallowing can be caused by acute tonsillitis, acute epiglottitis, mononucleosis pharyngitis and other diseases, which can be relieved by medication, surgery, daily care and other methods. 1. Acute tonsillitis: As acute tonsillitis causes a very sore throat and painful swallowing, you can follow the doctor’s advice to choose azithromycin tablets, ibuprofen extended-release capsules, dulcimerifen tablets and other medications for treatment, and to strengthen the nutrition, to ensure that sufficient protein and vitamins. 2. Acute epiglottitis: Due to acute epiglottitis caused by a very sore throat and painful swallowing, penicillin, avant-garde drugs, combined with dexamethasone and other glucocorticoids intravenous drip. If there is localized abscess formation, incision and drainage should be carried out. 3. mononucleosis pharyngitis: due to mononucleosis pharyngitis caused by a very sore throat and painful swallowing, antiviral treatment can be used acyclovir, ganciclovir and vasiclovir and other drugs. Intravenous immunoglobulin can improve clinical symptoms, shorten the course of the disease, early administration of the drug is more effective. alpha-interferon also has a certain therapeutic effect. If the throat is very painful, even when swallowing, you need to actively seek medical advice, systematic examination to clarify the diagnosis, and follow the doctor’s instructions to standardize the use of drugs and treatment.