Repeated episodes of closed mouth acne can be treated with chemical peeling and topical medication. 1. Chemical exfoliation: including amygdalic acid, fruit acid, salicylic acid, etc., can promote the epidermis and dermis superficial cell shedding, for closed mouth acne has a certain therapeutic effect. 2. Topical medications: can choose to use Vitamin A acid preparations, with the dissolution of micro-acne, regulating the keratinization of follicular mouth, commonly used medications are Vitamin A acid ointment, adapalene gel and so on. If the closed mouth acne repeatedly difficult to heal, should go to the regular hospital in a timely manner, in accordance with the doctor’s instructions for targeted treatment.