Urinary nuclear matrix protein nmp22 is a tumor marker used to screen for bladder cancer, and a positive urine nuclear matrix protein nmp22 represents a possible high risk for bladder cancer. As a tumor marker for bladder cancer, urinary nuclear matrix protein nmp22 has high sensitivity and specificity, but it does not mean that elevated levels of this protein in urine can diagnose bladder cancer, and this indicator can only be used as a reference basis for clinicians. The gold standard for the diagnosis of bladder cancer is still cystoscopic mass biopsy. Therefore, people with positive urine nuclear matrix protein nmp22 should go to regular hospitals for regular follow-up, exclude high-risk factors, and follow the guidance of professional physicians.