If the treatment of neonatal purulent meningitis is timely and successful, the damage to the brain parenchyma is mild and may not affect intelligence; if the damage to the brain parenchyma is more serious, it may leave many sequelae, such as hearing, intelligence, locomotion, language, and so on. Neonatal purulent meningitis is caused by bacterial infection in the skull, if only the meninges are infected, after active treatment, with the growth and development of the child, most of the children will not be left with intellectual disability. If the brain parenchyma damage is more serious, it may cause intellectual regression, at this time, active rehabilitation is necessary, the specific intellectual stay a few years old, with the degree of brain damage, the treatment process, the later rehabilitation are related. When septic meningitis is suspected in newborns, it is recommended to hospitalize the child in time for treatment and active rehabilitation during the recovery period to reduce the occurrence of sequelae.