The etiology of bone marrow failure is complex, including direct environmental damage, hereditary bone marrow failure syndrome, clonal disease, acquired re-injury and other causes.
1. Direct environmental damage: such as benzene as the representative of chemical pollution or medical origin of chemotherapy, radiotherapy and other causes of bone marrow injury. However, it is currently believed that there is a significant dose-dependence of such toxic effects, resulting in bone marrow damage is mostly transient and reversible.
2. Hereditary bone marrow failure syndrome: also known as congenital remyelination, is a group of bone marrow failure diseases with significant genetic characteristics, the main types include Fanconi anemia, congenital dyskeratosis, bone marrow failure syndrome with pancreatic exocrine enzyme deficiency and congenital megakaryocyte thrombocytopenia.
3. Clonal diseases: such as myelodysplastic syndrome and paroxysmal sleep hemoglobinuria.
4. Acquired remyelination: with T-cell immune-mediated as the main pathogenesis, it is the main type of bone marrow hematopoietic failure disease, and therefore is also the focus of clinical attention.
It is recommended to go to the hospital in time when the above mentioned diseases appear.