Ibuprofen should not be taken with other cold and flu medications. Ibuprofen belongs to the non-steroidal class of antipyretic and analgesic drugs, and cold and flu medications contain acetaminophen, which also belongs to the class of antipyretic and analgesic drugs. If the two medicines are taken together there is a possibility of an increase in side effects, belonging to the duplication of medication. If your body temperature does not exceed 38.5 degrees Celsius and you have symptoms such as nasal congestion, runny nose, sneezing, sore throat and coughing, you can take cold medicine alone. If the body temperature exceeds 38.5℃ 4-6 hours after taking cold medicine, accompanied by headache, muscle pain, fatigue and other symptoms, you can take ibuprofen orally to help relieve fever and analgesia, sweating, and reduce fever.