It is absolutely not allowed to drink alcohol after taking cefixime, because cefixime belongs to β-lactam antibiotics. All β-lactam antibiotics, such as cephalosporins, penicillins and carbapenems, are not allowed to drink alcohol and will cause a chemical reaction with alcohol. This chemical reaction is called disulfiram-like reaction, which may cause itching, rash, redness, swelling, heat, pain and skin dysfunction in mild cases, or chest tightness, shortness of breath, palpitations, precordial discomfort and dyspnea in severe cases, and dizziness, headache, nausea, vomiting in the most serious cases, and anaphylactic shock symptoms such as transient loss of consciousness. Therefore, you should never drink alcohol after taking cefixime, and if you must drink alcohol, you should wait for seven days after the cephalosporin has been completely metabolized in your body before you can drink a small amount of alcohol. If you feel sick after drinking alcohol, you need to go to the hospital immediately to avoid affecting and delaying your condition.