Clinical medications for pyelonephritis are mainly anti-infective drugs as well as symptom-improving drugs. Pyelonephritis is an infectious disease caused by bacteria and other pathogens, and the main treatment drugs are anti-infective drugs, such as penicillin, cephalosporin or quinolone antibiotics for bacterial infections, commonly used amoxicillin, cefuroxime, levofloxacin and so on. Fungal infections result in the need to apply antifungal drugs, such as itraconazole, voriconazole, fluconazole and so on. If the patient has obvious symptoms of bladder irritation, sodium bicarbonate can be applied to alkalize the urine and reduce the symptoms of bladder irritation. All kinds of drugs have side effects, such as penicillin, cephalosporin antibiotics have the possibility of severe allergies, quinolone antibiotics have the possibility of leading to cartilage underdevelopment, so the choice of drugs for pyelonephritis treatment needs to be chosen by the specialist according to the patient’s different causative organisms and should not be used on its own.