What is chronic fatigue syndrome? It refers to the state of non-disease and non-health, which is a state between health and disease, so it is also called “subhealth” and “sub-health”. The World Health Organization calls the state in which the body has no organic pathology but some functional changes as “third state”, and China calls it “subhealth state”. In other words, chronic fatigue syndrome refers to a group of systemic syndromes mainly manifested by long-term extreme fatigue (including physical and mental fatigue) under the modern efficient and fast-paced lifestyle, and may be accompanied by dizziness, headache, insomnia, forgetfulness, low fever, muscle and joint pain and various neuropsychiatric symptoms. The etiology of chronic fatigue syndrome is complex, and on the whole, it is closely related to the social environment, economic and cultural factors, psychological factors and one’s own physique, and modern medicine still lacks effective detection and treatment methods for it. According to Chinese medicine, the cause and mechanism of chronic fatigue syndrome mainly lies in the imbalance of yin and yang, qi and blood, and internal organs and body, caused by factors such as internal injury of the seven emotions, uncontrolled diet, irregular living, unrestrained labor, and old age and physical decay. The treatment of chronic fatigue syndrome belongs to the category of “treating the untreated disease”. Ancient medical doctors paid full attention to chronic fatigue syndrome and regarded “treating the untreated disease” as the performance of doctors’ excellent medical skills. Chronic fatigue syndrome” is a modern term, similar to “slack generation”, “slack generation” and “weakness” described in ancient Chinese medical texts. “Therefore, it is believed that the manifestation of chronic fatigue syndrome is more in the form of deficiency evidence. According to clinical observation, modern people have a tendency to increase the number of people with cold or deficient cold constitution year by year due to many factors such as the increasing pace of life and the constant change of diet and living. The specific manifestations are: cold and fear of cold, the limbs are not warm, women have dysmenorrhea, men have reduced sexual function, or eat cold that is abdominal pain, diarrhea, white tongue coating, and so on. Traditional Chinese moxibustion is one of the most effective means to dissipate fatigue, restore vital energy, replenish physical energy and balance yin and yang, and it is simple, inexpensive and free of toxic side effects, so it is suitable for large-scale application. The clinical study of moxibustion for chronic fatigue syndrome. Methods: 1, moxibustion across the medicine cake: according to the evidence of the disease, choose Guan Yuan, Qi Hai, Foot San Li and other points, the use of the drug “sapodilla”, cinnamon, safflower and other drugs to prepare the medicine cake, the application of moxibustion cones across the medicine cake for moxibustion, moxibustion, medicine, acupuncture synergistic effect of the three, in order to achieve the role of warming the meridians, warming and replenishing the qi and blood. 2. Combination of acupuncture and moxibustion: according to the evidence of the disease, choose mild moxibustion points such as Zhonggui, Guan Yuan, Qihai and Shen Que, use clear moxa strips, apply moxibustion apparatus for smoked moxibustion, and at the same time, cooperate with acupuncture points such as Dazhi, Shoulder Well, Tianzong and Kidney Yu, to give full play to the role of moxa in tonifying the spleen and stomach, warming the Yang and replenishing the Qi, and activating the channels. For busy patients, self-moxibustion treatment can be performed under the guidance of a doctor, using mild moxibustion method to moxibustion the above acupuncture points, in order to be comfortable, 10-15 minutes per point, once a day or every other day. Adherence to moxibustion can benefit qi and blood, smooth the meridians, and effectively treat chronic fatigue syndrome.