Infertility disease as we know it now, it is a big family is the most painful thing. There are many hospitals that treat infertility, and patients must choose a regular hospital to go to for treatment, what is the reason for not being able to conceive a child? Let’s take a look together. 1, vaginal factors Due to congenital factors such as vaginal atresia or vaginal septum cause sexual intercourse disorders or difficulties, thus affecting the sperm into the female reproductive tract. Furthermore, vaginal inflammation caused by mycobacteria, trichomonas and gonococcal infections changes the biochemical environment of the vagina and reduces sperm motility and viability, thus affecting the chance of conception. 2, cervical factors cervical stenosis, polyps, tumors, adhesions, etc. can affect the passage of sperm; cervical erosion, its inflammatory exudate has a spermicidal effect; cervical mucus in the presence of anti-sperm antibodies, which is not conducive to sperm penetration of the cervical canal or completely make sperm inactivity, which is noteworthy is the unmarried first pregnancy after abortion caused by cervical adhesions, especially repeated abortions are more likely to cause this serious combination. The sperm are rejected from the cervical opening. Congenital abnormalities of the cervical canal are often accompanied by abnormal menstruation or dysmenorrhea, and girls go to the hospital for examination after their first period. In contrast, cervicitis due to gonococcus and others is contracted through sexual intercourse and often leads to atresia or narrowing of the cervical canal. Atresia of the endocervix is one of the common causes of infertility due to habitual late miscarriage. When the weight of the fetal sac increases beyond the capacity of the cervical canal, the cervical canal dilates, the fetal sac bulges out and breaks the water, and the fetus and placenta are expelled one after another, which often occurs after the third month of pregnancy. 3.Uterus factor Congenital anometrium, infantile uterus and solid uterus without cavity are all dysplasia or malformation that can affect the fertility of women. Posterior or severe retroflexion of the uterus, endometrial inflammation, and uterine adhesions are all causes of infertility. About 75% of patients with endometriosis have a history of infertility because it causes posterior uterine adhesions and poor activity, which can also cause adhesions in the fallopian tubes, leading to decreased peristaltic capacity; ectopic endometrium can act as an autoantigen, causing hyperimmune function in women, such as the production of anti-endometrial antibodies; ectopic endometrium can also produce more prostaglandins, which can lead to uterine and fallopian tube muscle The ectopic endometrium can also produce more prostaglandins, which can lead to strong contractions of the muscles of the uterus and fallopian tubes, interfering with the movement of sperm and eggs and the implantation of the pregnant egg, thus causing infertility. Uterine fibroids are the most common benign tumor in women, and the infertility rate in patients with fibroids can be 30-40%, much higher than that of the general population. Among them, submucosal fibroids can affect the passage of sperm and the implantation of the embryo, while intermural fibroids not only affect conception but also often cause miscarriage or preterm delivery. Even if conception is possible, in late pregnancy, abnormal contraction of the uterus can cause preterm labor, obstruct delivery or cause postpartum hemorrhage. 4. Fallopian tube factors Long or narrow fallopian tubes, tubal inflammation causing luminal occlusion, fluid accumulation or adhesions can prevent the movement of sperm, eggs or fertilized eggs. Tubal disease can account for up to 25% of female infertility and is an important cause of infertility. Inflammatory diseases include tuberculosis, endometriosis, trichomonas, gonorrhea and other pathogenic infections. Blocked fallopian tubes can be recanalized through hysteroscopy, lavage, microsurgery, and IVF techniques can also be used to help patients gain a chance of pregnancy. 5. Ovarian factors Factors that affect follicular development or egg discharge, such as follicular underdevelopment in the ovary, inability to ovulate and form corpus luteum, premature ovarian failure, polycystic ovaries, ovarian tumors, etc., can cause infertility. For example, the follicle can mature but cannot rupture, so the egg cannot be expelled, its basal body temperature is normal biphasic, and the changes in blood hormone levels are completely normal, a condition called follicular non-rupture syndrome. Luteal insufficiency is a manifestation of insufficient progesterone secretion, which is mostly related to high prolactin levels, when the development of the secretory phase of the endometrium is affected and thus not conducive to fertilization of the egg, and even if it does, it will be aborted due to insufficient progesterone secretion. Polycystic ovary syndrome is characterized by non-ovulation. It is not an individual disease, but a general term for a series of clinical symptoms and signs, mostly manifesting as menstrual disorders (scanty menstruation or amenorrhea); infertility; bilateral ovarian enlargement, thickening of the envelope, polycystic changes; hirsutism, obesity, and increased libido. Infertility is caused by endocrine and menstrual disorders. Infertility is a condition that we need to pay special attention to these problems in ordinary times, because nowadays there are many people with signs of infertility, but our treatment needs to understand the reasons why he is sick and choose the right treatment method, and we must pay special attention to these problems.