Perianal discomfort burning sensation should be based on a clear cause of the medication, perianal discomfort burning sensation may be caused by perianal infection, anal fissure, perianal eczema, etc., the different causes of its treatment and drugs are different. Specific drugs are antibiotics, calcium-modulated phosphatase inhibitors and so on. 1. Perianal infection: cefixime, gentamicin, metronidazole and other antibiotics can be used to control the symptoms, abscess formation needs to be timely incision and drainage. 2. Anal fissure: may use Ma Yinglong musk hemorrhoid cream and other drugs. 3. Perianal eczema: can use calcium-modulated phosphatase inhibitors such as pimecrolimus and other medications, serious cases can be short-term use of glucocorticosteroids such as cortisone treatment. This symptom should be timely to the hospital, identify the cause, under the guidance of the doctor symptomatic treatment, avoid unauthorized use of drugs or treatment.