The causes of severe coughing that doesn’t stop at night may include lung infections, upper airway cough syndrome, and cough variant asthma. The treatment varies depending on the cause of the disease. Commonly used treatments include medication, etc. 1. Lung infection: As the lung parenchyma is infected by bacteria and other pathogens, it causes inflammation in the lungs, resulting in an increase in secretions and irritation of the airways, leading to the patient’s symptoms of severe coughing that won’t stop. You can choose drug treatment, such as cephalosporin antibiotic cefixime anti-infection, aminoglutethimide hydrochloride or bromhexine to stop cough and resolve phlegm and other symptomatic treatment. 2. Upper airway cough syndrome: generally in the nasal secretion increases lying down position easy to induce cough, in addition to coughing, coughing up sputum, the patient usually complains of pharyngeal drip flu, pharyngeal itching discomfort or nasal itching, nasal congestion, runny nose, sneezing and so on. Antihistamines such as chlorpheniramine maleate and decongestants such as pseudoephedrine hydrochloride can be used. 3. Cough variant asthma: mainly manifested as irritating dry cough, usually cough is more violent, night cough is its important feature. Colds, cold air, dust, fumes and so on can easily trigger or aggravate the cough. Most patients can inhale small doses of glucocorticoids plus beta agonists such as budesonide formoterol powder inhaler. Symptoms of a violent cough that won’t stop at night can also be caused by other diseases, such as heart failure and gastroesophageal reflux disease. If the symptoms are not relieved or aggravated, it is recommended that the patient go to the hospital in time to improve the relevant examination, to clarify the cause of the disease, and follow the doctor’s instructions for treatment, so as not to delay the condition.