Since chromosome 16 is an autosome and is not related to gender, it is not certain whether it comes from the female or male side and requires genetic examination of both parents. If both parents have normal chromosomes and the child has chromosome 16 abnormalities, this could be due to a genetic mutation during embryonic development or an abnormal undisjunction of the chromosomes during meiosis, resulting in a child with chromosome 16 trisomy. It can also be due to one of the parents, who is a carrier of chromosome 16 trisomy, and all of the above are causes of chromosome 16 trisomy in a child. Therefore, it is not possible to determine whether the cause of its occurrence is from the father, the mother or the child itself simply by analyzing the child’s karyotype; it is specifically necessary to go through the analysis of family members to clarify the cause of the child’s chromosomal genetic abnormality. However, in either case, if the chromosomal genetic abnormality has been detected during the embryonic period, i.e. during the mother’s pregnancy, it is recommended to terminate the pregnancy immediately.