There are no obvious symptoms in mild cases of osteoporosis, but as the disease worsens, patients will suffer from pain, fatigue, bone fracture, spinal deformation and other symptoms. 1. Pain: With the aggravation of osteoporosis, the bones of the whole body will change, which will easily lead to pain in the limbs, or even pain in the bones of the whole body. 2. Weakness: mainly due to the decline in bone strength caused by the disease, the joints are seriously degraded and feel weak, especially the lower limbs are weak. 3. Fracture: when bone strength decreases, the brittleness of bone increases, and minor trauma may lead to fracture. 4. Spinal deformation: As osteoporosis is more serious, it can lead to vertebral compression fracture, thus causing spinal deformation, which is manifested as shortening and hunchback. Osteoporosis may also cause some other symptoms, which should be consulted in time.