If the anus is always wet and smelly, oral medication can be administered depending on the cause of the onset. First of all, it may be due to anal eczema which will lead to wet, itchy, inflamed and smelly anal area. It is possible to take oralloxacin capsules, Xithromax, Benadryl hydrochloride and so on, and then apply the treatment with mometasone furoate cream. Secondly, it may be caused by perianal abscess, which can be treated with metronidazole and gentamicin for enema, and can be treated with oral metronidazole, etimesine sulfate and Huanglian detoxification soup. If the result is not good, surgical incision and drainage is also required. If it is due to hemorrhoids, you need to take oral hemorrhoid tablets, Triphala tablets, Sophora, etc. for treatment. Finally, it is not excluded that the condition is caused by anal sinusitis, anal fissure, etc.. You can go to the hospital for a distinguishing examination and then do the appropriate treatment.