There are several possible causes of pain in the middle of the waist: first, supraspinous ligamentitis and interspinous ligamentitis, these two diseases can often lead to pain in the middle spinous process or interspinous process of the waist, and it is necessary to conduct relevant examinations of the lumbar spine to exclude other diseases for diagnosis. Second, lumbar instability and lumbar spine slippage, which can appear lumbar pain, accompanied by restricted lumbar activities, pain can often be like a lumbar fracture, then the lumbar X-ray, CT, nuclear magnetic examination should be carried out for diagnosis and treatment. Third, rheumatoid diseases, when rheumatoid involvement of the spine, can appear in the middle of the waist pain, then to carry out the relevant lumbar spine X-ray, nuclear magnetic examination and blood tests, diagnosis and treatment. Fourth, osteoporosis of the lumbar spine, osteoporotic low back pain can appear in the middle of the waist pain, then the lumbar spine X-ray, nuclear magnetic examination and blood tests for diagnosis. Fifth, ankylosing spondylitis, ankylosing spondylitis can involve the lumbar spine, can appear in the middle of the waist pain, then to carry out blood tests and lumbar spine X-ray, nuclear magnetic examination, diagnosis and treatment.