53 years old patients with high pressure 147mmHg and low pressure 100mmHg can take diuretics, beta receptor antagonists, calcium channel blockers, angiotensin-converting enzyme inhibitors, and angiotensin II receptor antagonists under the guidance of a doctor. 1. Diuretics: such as hydrochlorothiazide, which has a smoother onset of action and lasts for a longer period of time, is suitable for people with mild or moderate hypertension, or those with obesity or diabetes. However, hypokalemia, fatigue, increased urine output and other uncomfortable symptoms can occur. It is not recommended for gouty people. 2. β-receptor antagonists: such as propranolol, metoprolol, etc., with fast onset of action. They are suitable for middle-aged and young hypertensive patients with fast heart rate, but their efficacy is poor for elderly hypertension. Bradycardia, fatigue, cold extremities may occur when using the adverse reactions, and at the same time, it is forbidden for patients with acute heart failure, sick sinus node syndrome, atrioventricular block. 3. Calcium channel blockers: such as nifedipine, verapamil and so on. They have rapid onset of action, have no significant effect on blood lipids and blood glucose, and have good antihypertensive efficacy in elderly patients. However, heart rate increase, headache, lower extremity edema and other uncomfortable symptoms can occur. 4. Angiotensin converting enzyme inhibitors: such as captopril. Enalapril, etc., slow onset of action, on obesity, and suffering from diabetes, renal impairment of hypertensive patients with better efficacy, but may appear irritating dry cough and angioedema. Severe renal insufficiency, pregnancy, bilateral renal artery stenosis, patients with contraindication 5. Angiotensin II receptor antagonist: such as chlorosartan, irbesartan, etc., slow onset of action, less adverse reactions. Hypertensive patients must follow the doctor’s instructions when taking medication, low-salt, low-fat diet, strengthen physical exercise, weight control, if the blood pressure is still excessive need to use drugs to control.