The disadvantages of perindopril amlodipine tablets are mainly the more expensive price, as well as some adverse effects. 1. Expensive: Perindopril amlodipine tablets are used for adult patients whose high blood pressure cannot be adequately controlled by monotherapy; or patients whose high blood pressure is still poorly controlled by the combination of perindopril and amlodipine at the same dosage level; the price of the drug is relatively expensive, about 5-6 dollars for a piece of medicine, which can be a financial burden for some patients with general economic conditions who have been taking it for a long time. 2. Adverse reactions: Perindopril amlodipine is a combination of perindopril and amlodipine, and its adverse reactions will include the adverse reactions of these two drugs, perindopril common adverse reactions include dizziness, headache, low blood pressure, cough and so on. Common adverse reactions to amlodipine include arrhythmia, hypotension, and peripheral local ischemia; the combination of the two may increase the incidence of overlapping adverse reactions; the drug is contraindicated in patients who are allergic to any of the components of perindopril or amlodipine, or who are hypotensive, or who are in shock. The specific use of the drug needs to be taken under the guidance of a professional physician, do not unauthorized use or discontinuation of medication to avoid adverse reactions.