Numbness in the left leg and foot requires active search for the cause and appropriate etiologic treatment. A common cause of numbness in the left leg and foot is cerebrovascular disease, mainly seen in the right basal ganglia area, radiocoronal area or lacunar cerebral infarction. Its treatment mainly consists of oral aspirin against platelet aggregation, or clopidogrel if aspirin is not tolerated, and the application of statins, such as simvastatin, resulvastatin and atorvastatin, to regulate lipids and stabilize plaque. At the same time, blood circulation can be improved as well as neuroprotective treatment. Drugs to improve blood circulation are generally applied to shuxin, vincristine and trimethoprim, and drugs commonly used for neuroprotective treatment are edaravone, cerebroprotein hydrolysate, oracetam and piracetam, etc.