Infections with H. pylori and mycoplasma can be treated with a combination of medications, but it is usually sufficient to treat H. pylori alone, as H. pylori is treated with a quadruple combination of medications, which includes antibiotic medications that treat mycoplasma infections. Helicobacter pylori is often taken systematic quadruple therapy, that is, a proton pump inhibitor, a bismuth agent and two antibiotic drugs, of which the proton pump inhibitor is commonly used omeprazole, lansoprazole, rabeprazole, bismuth agent commonly used bismuth pectin, bismuth potassium citrate, antibiotic drugs are generally used amoxicillin, clarithromycin, levofloxacin, metronidazole and so on. The above drugs should be taken under the guidance of a doctor, not to self-medication, and during the treatment of Helicobacter pylori can not be stopped at will to reduce the drug, to adhere to the doctor’s treatment.