There is no absolute fastest and most effective way to treat headache. Headache may be a physiological condition that does not require medication. Pathological conditions, such as high blood pressure, migraine and other causes of headache need to be directed at the cause of the drug treatment, such as oral timosartan, zolmitriptan and so on. 1. Physiological conditions: such as fatigue, sleep deprivation can appear headache symptoms, rest and improve sleep can be relieved, no need for medication, headache can be severe oral ibuprofen and other non-steroidal anti-inflammatory drugs to relieve pain symptomatic treatment. 2. Hypertension: elevated blood pressure can appear headache, swelling pain, etc., you can take oral antihypertensive drugs, such as timosartan, nifedipine controlled-release tablets, felodipine and other drugs to lower blood pressure treatment, headache symptoms can be relieved after the blood pressure control is stable. 3. Migraine: episodic, mostly lateral, moderate to severe, throbbing headache, can be taken orally zolmitriptan, ergotamine and other medications to relieve pain and symptomatic treatment, usually should avoid migraine triggering factors. 4. Other: such as upper respiratory tract infections, intracranial infections and other diseases can be manifested as headache symptoms, can be given acyclovir, cefuroxime and other drugs. The causes of headaches are many, need to clarify the cause of targeted treatment, do not blindly pursue the fastest and most effective and unauthorized use of drugs, so as not to cause adverse effects on the body.