Proteinuria that is negative on medication and then recurs again when the medication is stopped often requires a repeat of the previous treatment regimen or an adjustment to the regimen. Drugs that have the effect of reducing urinary protein are mainly glucocorticoids, such as prednisone, methylprednisone and other drugs. Prilosec or sartans, also have the effect of assisting in lowering urinary protein, but this drug is usually long-term maintenance, most will not stop the drug. The use of hormones to reduce urinary protein, after a period of time will be withdrawn from the drug, after stopping the drug some patients may relapse. At this time, it is often necessary to re-use the original dose of hormones, or hormones combined with immunosuppressive drugs, the latter commonly used drugs are cyclophosphamide, tacrolimus and so on. All of the above drugs have certain side effects, especially hormones and immunosuppressants may induce infections, peptic ulcers, osteoporosis and other serious consequences, and should be used in accordance with medical advice.