Primary unilateral knee osteoarthropathy generally refers to the degenerative disease of the knee joint, and the treatment mainly relieves the symptoms through oral medication, injectable medication, and surgical treatment. 1. Oral medication: For patients with mild symptoms, non-steroidal anti-inflammatory painkillers such as ibuprofen and diclofenac sodium can be taken orally, together with the use of nutritive cartilage repairing medications such as glucosamine, etc., to relieve the pain caused by primary unilateral knee osteoarthropathy. 2. Drug injection: If the effect of oral medication is not satisfactory or the pain symptoms are serious, local closed treatment can also be carried out, injecting drugs such as sodium vitrate into the joint cavity, which can effectively improve the friction in the joint area, relieve the joint pain symptoms, and alleviate the discomfort in the joint area. 3. Surgery: For patients with severe symptoms, if the joint space is significantly narrowed, accompanied by a large number of osteophytes, seriously affecting the quality of life, surgery can be used to clean up the joint lesions and improve the clinical symptoms. Patients with primary unilateral knee disease should pay attention to the protection of the knee joint in daily life, avoiding frequent bending of the knee, weight-bearing, running, climbing and other actions, and should go to the hospital in time when there are symptoms of discomfort, so as to clarify the cause of the disease and carry out standardized treatment.