Waking up with shortness of breath during sleep is commonly associated with pathologic conditions such as acute exacerbation of chronic obstructive pulmonary disease and heart failure. Upper respiratory tract infections lead to nasal congestion and blockage. To clarify the cause, it is necessary to further go to the hospital to improve laboratory tests, and give appropriate treatment for the disease. Most people sleep flat on their backs, and if there is shortness of breath that wakes them up, it is more common that there is a pathologic disease. The existence of chronic obstructive pulmonary disease, especially in acute exacerbation will have obvious chest tightness, shortness of breath, dyspnea, difficult to lie down, sleep may be suffocated to wake up, this situation needs to further improve the chest CT, lung function, blood gas analysis and other laboratory tests. Oxygen, anti-inflammatory, improve airway spasm and other treatments are given after the diagnosis is clear. Patients with heart failure may be awakened during sleep due to increased return blood volume, increased cardiac preload, and increased pulmonary stasis, which may lead to chest tightness, shortness of breath, and dyspnea, and may be suffocated, and need to go to the Department of Cardiology to improve cardiac ultrasound, chest CT and other laboratory tests. After a clear diagnosis, diuretic, cardiotonic, oxygen and other treatments need to be given. Upper respiratory tract infections, nasal congestion increases during sleep, there will also be difficulty in ventilation, shortness of breath to wake up the situation, sit up after the symptoms will improve, can apply pseudoephedrine drugs to reduce nasal congestion. Specifically to determine what causes the shortness of breath during sleep to wake up, it is recommended to further go to the appropriate department of the hospital for consultation.