Once the headache at night, mainly consider the following aspects of the cause: First, if it is hypertensive patients once the headache at night, to continuously monitor the blood pressure situation. There are some patients with unstable blood pressure control, if there is an increase in blood pressure, there will be a headache, at this time need to give oral antihypertensive drugs, blood pressure is normal after the patient’s headache can be relieved. Secondly, if the headache is painful at night, ask the patient if he/she has any past history of migraine, some migraine is prone to fixed time or fixed site headache when acute attack occurs. Third, once the head hurts at night, ask the patient if there is fever, if it is accompanied by nausea and vomiting, and also go for EEG examination. Some atypical epilepsy can also manifest as fixed-time headache.